This food has been shown in various studies to help musculoskeletal symptoms and inflammation in general. The yellow pigment in Turmeric (curcumin) has been shown to have a potent anti-inflammatory effect comparable to prescription anti inflammatory drugs and consumption has been shown to be inversely related to the incidence of Alzheimer’s (a disease which is also thought to have an inflammatory basis.
· Tumeric may be helpful in many conditions where inflammation is mediating the disease pathology such as Inflammatory Bowel Disease,
· Turmeric may help Cystic Fibrosis in experimental models, It has also been shown to prevent cancer in animal models of breast cancer and Non-Hodgkins lymphoma.
· Significantly turmeric seems to prevent precancerous colonic polyps from developing in clinical studies. Quercetin, an anti-oxidant flavonoid found in onions, green tea and red wine, was also shown a similar effect. Studies combining curcumin with phenethyl isothiocyanates, a phytochemical abundant in cruciferous vegetables including cauliflower, cabbage, broccoli, Brussels sprouts, kale, kohlrabi and turnips significantly reduced both prostatic tumour cell growth and spread in animal studies.
· Population studies suggest inverse correlation between child hood leukaemia and turmeric consumption
· Turmeric may help to improve liver function in animal models, in humans turmeric consumptions dropped cholesterol levels in blood and improved overall lipid profile
· Turmeric may protect against neurodegenerative diseases. and this supported by population studies which show that Alzheimer's are very low in aging Indian and other Asian populations . Mechanisms of action include production of antioxidant proteins inhibition of amyloid  aggregation and boost Amyloid Plaque Clearance
Key Referances Aggarwal B. October 5, 2005,. reported in NUTRAingredients.com/Europe "Turmeric slows breast cancer spread in mice.". Balasubramanian K. Molecular Orbital Basis for Yellow Curry Spice Curcumin's Prevention of Alzheimer's Disease. J. Agric. Food Chem., 54 (10), 3512 -3520, 2006. 10.1021/jf0603533 S0021-8561(06)00353-0, Web Release Date: April 20, 2006. Calabrese V, et al Nutritional antioxidants and the heme oxygenase pathway of stress tolerance: novel targets for neuroprotection in Alzheimer's disease. Ital J Biochem. 2003 Dec;52(4):177-81. Calabrese V, et. al. Paper on curcumin's induction of hemeoxygenase-1. American Physiological Society, April 17-21, 2004, Washington, D.C. Cruz-Correa M, et al Combination treatment with curcumin and quercetin of adenomas in familial adenomatous polyposis. Clin Gastroenterol Hepatol. 2006 Aug;4(8):1035-8. Deshpande UR, al. Protective effect of turmeric (Curcuma longa L.) extract on carbon tetrachloride-induced liver damage in rats. Indian J Exp Biol 1998 Jun;36(6):573-7. Dorai T et al. Therapeutic potential of curcumin in human prostate cancer. Curcumin inhibits proliferation, induces apoptosis, and inhibits angiogenesis of LNCaP prostate cancer cells in vivo. Prostate 2001 Jun 1;47(4):293-303. Egan ME, et al Curcumin, a major constituent of turmeric, corrects cystic fibrosis defects. Science. 2004 23;304(5670):600-2. Lim GP,et al. The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. J Neurosci 2001;21:8370-7. Nagabhushan et al. In vitro antimutagenicity of curcumin against environmental mutagens. Food Chem Toxicol. 1987 25(7):545-7. Nagabhushan et al . Curcumin as an inhibitor of cancer. J Am Coll Nutr. 1992;11:192-8. Park et al Discovery of natural products from Curcuma longa that protects cells from beta-amyloid insult: a drug discovery effort against Alzherimer's disease. J Nat Prod 2002;65(9):1227-31. Shishodia S, et al Curcumin (diferuloylmethane) inhibits constitutive NF-kappaB activation, induces G1/S arrest, suppresses proliferation, and induces apoptosis in mantle cell lymphoma. Biochem Pharmacol. 2005 ;70:700-13. Soni KB, at al Effect of oral curcumin administration on serum peroxides and cholesterol levels in human volunteers. Indian J Physiol Pharmacol. 1992 Oct;36(4):273-5. Zhang L, et al Curcuminoids enhance amyloid-beta uptake by macrophages of Alzheimer's disease patients. J Alzheimer’s Dis. 2006 Sep;10(1):1-7.
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